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Preclinical Pharmacology and Toxicology

Depression

  • Porsolt swim test in rat
  • Tetrabenazine test in mouse or rat

We have substantial experience in running the swim test for commercial clients and are set up to evaluate compounds on short notice.

Publications

Howard, J.L., Soroko, F.E., & Cooper, B.R. (1981). Empirical behavioral models of depression, with emphasis on tetrabenazine antagonism. In Enna, S.J., Malick, J.B., & Richelson, E. (Eds.), Antidepressants: Neurochemical, Behavioral, and Clinical Perspectives (pp. 107-120). New York: Raven Press.

Cooper, B.R., Howard, J.L., & Soroko, F.E. (1983). Animal models used in prediction of antidepressant effects in man. Journal of Clinical Psychiatry, 44, 63-66.

Howard, J.L., Ferris, R.M., Cooper, B.R., Soroko, F.E., Wang, C.M., & Pollard, G.T. (1989). Models of depression used in the pharmaceutical industry. In Koob, G.F., Ehlers, C.L., & Kupfers, D.J. (Eds.), Animal Models of Depression (pp. 187-203). Boston: Birkhauser.

Cooper, B.R., White, H.L., Beek, O., Norton, R.M., Rigdon, G.C., Howard, J.L., Kraemer, G.W., & Ferris, R.M. (1992). Overview of the CNS pharmacology of BW 1370U87: A chemically novel, reversible, selective MAO-A inhibitor with potential to be a new antidepressant drug. Drug Development Research, 25, 181-190.

Beardsley, P.M., Howard, J.L., Shelton, K.L., & Carroll, F.I. (2005) Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock-stressors vs cocaine-primes and its antidepressant-like effects in rats. Psychopharmacology, 183, 118-126.