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Preclinical Pharmacology and Toxicology

Pain and Inflammation

  • Hot plate in mouse or rat
  • Formalin-induced paw licking in mouse
  • Carrageenan-induced hyperalgesia in rat
  • Phenylquinone- or acetic acid-induced writhing in mouse
  • Mustard oil-induced visceral pain in mouse (TRP A1)
  • Carrageenan-induced pleurisy in rat
  • Adjuvant-induced arthritis in rat
  • Tail flick in mouse or rat
  • Other tests that can be set up: Chung model of neuropathic pain

As with MES, the simple mouse models allow high throughput and economies of scale.

Publications

Chang, K.J., Rigdon, G.C., Howard, J.L., & McNutt, R.W. (1993). A potent and selective non-peptide delta-receptor agonist. Journal of Pharmacology and Experimental Therapeutics, 267, 852-857.